They alert us when OverDrive services are not working as expected. Without these cookies, we won't know if you have any performance-related issues that we may be able to address. These cookies help us understand user behavior within our services.
- ISBN 10: 0071464743.
- Navigation menu;
- Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis | Plant Physiology?
For example, they let us know which features and sections are most popular. This information helps us design a better experience for all users. Emphasizes understanding key concepts rather than merely memorizing facts Packed with self-study questions, explicit diagrams, and clinical examples Includes current and up-to-date basic and clinical science concepts Printed Pages: Seller Inventory BV.
Book Description McGraw-Hill.
Cell Physiology (Lange Physiology)
Soft cover. Book Description - -. David Landowne. This specific ISBN edition is currently not available. View all copies of this ISBN edition:. Synopsis About this title Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Emphasizes understanding key concepts rather than merely memorizing facts Packed with self-study questions, explicit diagrams, and clinical examples Includes current and up-to-date basic and clinical science concepts "synopsis" may belong to another edition of this title.
Buy New Learn more about this copy. Other Popular Editions of the Same Title. Search for all books with this author and title. Customers who bought this item also bought. However, some types are much quieter, and may go for minutes or longer without emitting any action potentials. Action potentials result from the presence in a cell's membrane of special types of voltage-gated ion channels. Thus, a voltage-gated ion channel tends to be open for some values of the membrane potential, and closed for others.
In most cases, however, the relationship between membrane potential and channel state is probabilistic and involves a time delay. Ion channels switch between conformations at unpredictable times: The membrane potential determines the rate of transitions and the probability per unit time of each type of transition. Voltage-gated ion channels are capable of producing action potentials because they can give rise to positive feedback loops: The membrane potential controls the state of the ion channels, but the state of the ion channels controls the membrane potential.
Thus, in some situations, a rise in the membrane potential can cause ion channels to open, thereby causing a further rise in the membrane potential. An action potential occurs when this positive feedback cycle Hodgkin cycle proceeds explosively. The time and amplitude trajectory of the action potential are determined by the biophysical properties of the voltage-gated ion channels that produce it.
Several types of channels capable of producing the positive feedback necessary to generate an action potential do exist. Voltage-gated sodium channels are responsible for the fast action potentials involved in nerve conduction. Slower action potentials in muscle cells and some types of neurons are generated by voltage-gated calcium channels.
Each of these types comes in multiple variants, with different voltage sensitivity and different temporal dynamics. The most intensively studied type of voltage-dependent ion channels comprises the sodium channels involved in fast nerve conduction. These are sometimes known as Hodgkin-Huxley sodium channels because they were first characterized by Alan Hodgkin and Andrew Huxley in their Nobel Prize-winning studies of the biophysics of the action potential, but can more conveniently be referred to as Na V channels.
Faculty Database Production Server | David Geffen School of Medicine at UCLA
The "V" stands for "voltage". An Na V channel has three possible states, known as deactivated , activated , and inactivated. The channel is permeable only to sodium ions when it is in the activated state.
- Bullets, Blood and Broken Bodies: the extraordinary criminal career of Buller Ward?
- Physiological Plant Ecology II?
- Telomeres and Aging | Physiological Reviews.
When the membrane potential is low, the channel spends most of its time in the deactivated closed state. If the membrane potential is raised above a certain level, the channel shows increased probability of transitioning to the activated open state. The higher the membrane potential the greater the probability of activation.
Once a channel has activated, it will eventually transition to the inactivated closed state. It tends then to stay inactivated for some time, but, if the membrane potential becomes low again, the channel will eventually transition back to the deactivated state. This is only the population average behavior, however — an individual channel can in principle make any transition at any time.
However, the likelihood of a channel's transitioning from the inactivated state directly to the activated state is very low: A channel in the inactivated state is refractory until it has transitioned back to the deactivated state. The outcome of all this is that the kinetics of the Na V channels are governed by a transition matrix whose rates are voltage-dependent in a complicated way.
Since these channels themselves play a major role in determining the voltage, the global dynamics of the system can be quite difficult to work out. Hodgkin and Huxley approached the problem by developing a set of differential equations for the parameters that govern the ion channel states, known as the Hodgkin-Huxley equations. These equations have been extensively modified by later research, but form the starting point for most theoretical studies of action potential biophysics. As the membrane potential is increased, sodium ion channels open, allowing the entry of sodium ions into the cell.
This is followed by the opening of potassium ion channels that permit the exit of potassium ions from the cell.
The inward flow of sodium ions increases the concentration of positively charged cations in the cell and causes depolarization, where the potential of the cell is higher than the cell's resting potential. The sodium channels close at the peak of the action potential, while potassium continues to leave the cell. The efflux of potassium ions decreases the membrane potential or hyperpolarizes the cell. This results in a runaway condition whereby the positive feedback from the sodium current activates even more sodium channels. Thus, the cell fires , producing an action potential. Currents produced by the opening of voltage-gated channels in the course of an action potential are typically significantly larger than the initial stimulating current.
Thus, the amplitude, duration, and shape of the action potential are determined largely by the properties of the excitable membrane and not the amplitude or duration of the stimulus. This all-or-nothing property of the action potential sets it apart from graded potentials such as receptor potentials , electrotonic potentials , subthreshold membrane potential oscillations , and synaptic potentials , which scale with the magnitude of the stimulus. A variety of action potential types exist in many cell types and cell compartments as determined by the types of voltage-gated channels, leak channels , channel distributions, ionic concentrations, membrane capacitance, temperature, and other factors.
The principal ions involved in an action potential are sodium and potassium cations; sodium ions enter the cell, and potassium ions leave, restoring equilibrium. Relatively few ions need to cross the membrane for the membrane voltage to change drastically. The ions exchanged during an action potential, therefore, make a negligible change in the interior and exterior ionic concentrations.
The few ions that do cross are pumped out again by the continuous action of the sodium—potassium pump , which, with other ion transporters , maintains the normal ratio of ion concentrations across the membrane. Calcium cations and chloride anions are involved in a few types of action potentials, such as the cardiac action potential and the action potential in the single-cell alga Acetabularia , respectively. Although action potentials are generated locally on patches of excitable membrane, the resulting currents can trigger action potentials on neighboring stretches of membrane, precipitating a domino-like propagation.
In contrast to passive spread of electric potentials electrotonic potential , action potentials are generated anew along excitable stretches of membrane and propagate without decay.
- Cardiovascular Physiology (Lange Physiology Series).
- Easy Ways to Enlarge Your German Vocabulary (Dover Language Guides German)?
- Download Gastrointestinal Physiology Lange Physiology Series.
- Paddington Abroad (Paddington Bear Book 4).
- Keyword Search;
- Recommended for you.
Regularly spaced unmyelinated patches, called the nodes of Ranvier , generate action potentials to boost the signal. Known as saltatory conduction , this type of signal propagation provides a favorable tradeoff of signal velocity and axon diameter. Depolarization of axon terminals , in general, triggers the release of neurotransmitter into the synaptic cleft. In addition, backpropagating action potentials have been recorded in the dendrites of pyramidal neurons , which are ubiquitous in the neocortex.
A neuron 's ability to generate and propagate an action potential changes during development. How much the membrane potential of a neuron changes as the result of a current impulse is a function of the membrane input resistance. As a cell grows, more channels are added to the membrane, causing a decrease in input resistance. A mature neuron also undergoes shorter changes in membrane potential in response to synaptic currents. Neurons from a ferret lateral geniculate nucleus have a longer time constant and larger voltage deflection at P0 than they do at P Immature neurons are more prone to synaptic depression than potentiation after high frequency stimulation.
In the early development of many organisms, the action potential is actually initially carried by calcium current rather than sodium current. The opening and closing kinetics of calcium channels during development are slower than those of the voltage-gated sodium channels that will carry the action potential in the mature neurons. The longer opening times for the calcium channels can lead to action potentials that are considerably slower than those of mature neurons.
Telomeres and Aging
During development, this time decreases to 1 ms. There are two reasons for this drastic decrease. First, the inward current becomes primarily carried by sodium channels. In order for the transition from a calcium-dependent action potential to a sodium-dependent action potential to proceed new channels must be added to the membrane.
If Xenopus neurons are grown in an environment with RNA synthesis or protein synthesis inhibitors that transition is prevented. If action potentials in Xenopus myocytes are blocked, the typical increase in sodium and potassium current density is prevented or delayed.
This maturation of electrical properties is seen across species. Xenopus sodium and potassium currents increase drastically after a neuron goes through its final phase of mitosis. Several types of cells support an action potential, such as plant cells, muscle cells, and the specialized cells of the heart in which occurs the cardiac action potential.